General Information

  • ID:  hor003688
  • Uniprot ID:  P83382
  • Protein name:  Periviscerokinin-1
  • Gene name:  NA
  • Organism:  Locusta migratoria (Migratory locust)
  • Family:  Periviscerokinin family
  • Source:  animal
  • Expression:  Found in the abdominal ganglia and perisympathetic organs. Not detected in the thoracic ganglia, subesophageal ganglion, corpora cardiaca, corpora allata, hypocerebral ganglion or frontal ganglion.
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Locusta (genus), Oedipodinae (subfamily), Acrididae (family), Acridoidea (superfamily), Acridomorpha, Acrididea (infraorder), Caelifera (suborder), Orthoptera (order), Polyneoptera (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005184 neuropeptide hormone activity
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  AAGLFQFPRV
  • Length:  10
  • Propeptide:  AAGLFQFPRV
  • Signal peptide:  NA
  • Modification:  T10 Valine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Myotropic activity
  • Mechanism:  NA
  • Cross BBB:  NO
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor003688_AF2.pdbhor003688_ESM.pdb

Physical Information

Mass: 126602 Formula: C53H80N14O12
Absent amino acids: CDEHIKMNSTWY Common amino acids: AF
pI: 10.55 Basic residues: 1
Polar residues: 1 Hydrophobic residues: 6
Hydrophobicity: 72 Boman Index: -98
Half-Life: 4.4 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 88
Instability Index: 1318 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  11897380
  • Title:  Identification of the Abundant Neuropeptide From Abdominal Perisympathetic Organs of Locusts.
  • PubMed ID:  12504101
  • Title:  Mass Spectrometric Analysis of the Perisympathetic Organs in Locusts: Identification of Novel Periviscerokinins